Expression and clinicopathological characteristics of PDX1, PTF1A, and SALL4 in large and small ducts of ectopic pancreas located in gastro-duodenum and jejunum

An ectopic pancreas is defined as pancreatic tissue outside its normal location, anatomically separated from the pancreas.The transcription factor pancreas/duodenum homeobox protein 1 (PDX1) involved in maintaining and functions early development, beta cell differentiation, endocrine non cells. Pancreatic subunit alpha (PTF1A) affects exocrine formation regulation of acinar identity, expressed cells a factor. The depletion SALL4 disrupts self-renewal induces differentiation.To clarify which PDX1, PTF1A, or determines difference Heinrich's classification, we examined localization number positive We analyzed differential expression large small ducts by immunohistochemistry. Results showed that PTF1A-positive was more widespread type I than II gastro-duodenum, SALL4-positive were noticed gastro-duodenum II. Our results revealed PTF1A might promote differentiation developing tissues, those with differentiate into